ea0070aep785 | Reproductive and Developmental Endocrinology | ECE2020
Hage Mirella
, Drui Delphine
, Ecomard Marie-Adèle
, Mercier Sandra
, Guiochon-Mantel Anne
, Belaisch-Allart Joelle
, Cazabat Laure
, De Mazancourt Philippe
, Raffin-Sanson Marie-Laure
Context: Androgen insensitivity syndrome (AIS) is a rare X-linked recessive disordercaused by mutations in the androgen receptor (AR) gene resulting in variable target tissue resistance to androgen action. The underlying molecular defect causes a spectrum of androgen dysfunction ranging from gynecomastia and/or infertility in mild AIS (MAIS) to variable degrees of ambiguous or undermasculinized genitalia in partial AIS to complete testicular feminization in complete A...